The Best CBD Creams for Depression

A few studies have recognized CBD as a natural antidepressant. Although this cannabis molecule isn’t a substitute for therapy or psychological treatment, it does have the ability to lift your mood. In fact, an increasing number of people are using CBD to relieve mental symptoms like depression and anxiety, rather than just physical ones.

In this article, we’ll go over the benefits of using CBD for depression. We’ll also address why using a topical product like a cream can be the perfect option. Finally, you’ll find some practical tips on using CBD cream for depression, and our top picks for the best products on the market today. 

cbd cream for depression

The Benefits of CBD Cream for Depression 

CBD is a molecule extracted from the cannabis plant. Over the years, scientists have discovered that it has a wide range of properties that can help people with their mental health symptoms. For example, it can naturally lift up your mood, relieve stress and anxiety, promote better sleep, and even make you more comfortable in social situations! 

So how does it work? When you take CBD, it binds with some of the thousands of endocannabinoid receptors that are found all over your body. When you take CBD through the mouth, it binds with receptors found along the digestive tract before entering your bloodstream. And when you apply CBD to your skin, it binds with subcutaneous endocannabinoid receptors, those located just underneath the first layer of the epidermis. 

When CBD binds with endocannabinoid receptors, it sends signals to your whole body that can relieve many symptoms. Among other benefits, you can experience a near-instant mood lift and relief from anxiety. Some people also find that taking CBD regulates their energy levels, which could be great for people with depression who experience lethargic periods. 

One of the great benefits of taking CBD through the skin rather than through the mouth is that the results are noticeable a lot faster. Because CBD doesn’t have to go through your whole digestive tract before reaching your system, you can expect to feel its effects in just 10 or 15 minutes. For people with depression, feeling those results instantly can give them the motivation they need to keep on supplementing with CBD. 

How to use CBD Cream for Depression

Before you start using CBD cream for your depression, it’s good to figure out what kind of product is right for you. In the world of CBD creams, there are a lot more options than you might imagine. From thick balms to lotions and face creams, there are a lot of different formulations and potencies to choose from.

CBD balms are generally thicker than creams, and they tend to have a higher potency. These products are great for applying on your temples, forehead, or the nape of your neck. These are also great spots to target for mental health symptoms. And with a high-potency product, you will only need to use a small amount to feel its effects. This means that having a thick balm that you can carry around with you is a great way to feel the mood-lifting benefits of CBD on the go.

CBD creams and lotions are a lot easier to apply on large areas of skin. If you’re planning on using CBD on your whole body, these are definitely the products that you should go for. A thin lotion can be used as a massage oil to apply all over your back or give yourself a little shoulder massage, for example. This can be a great way to turn taking CBD into a self-care ritual. Every night before bed, you can give yourself a little massage with CBD cream, taking the time to check in with yourself. Not only will it relax your muscles in preparation for sleep, but it’s also a great way to create a sense of routine.

cbd for depression
Endoca Hemp Salve

1. Endoca Hemp Salve 750 mg

This very high-potency balm is another all-natural product crafted by Dutch brand Endoca.

It contains a whole 750 mg of CBD in a relatively small 30-ml tub. This means that applying even a dollop-sized amount of the salve to your temples can have strong effects. If you’re looking for a powerful product that helps you feel the effects of CBD instantly, this may be the one for you. 

Over the years, Endoca have acquired a reputation for making very high-quality CBD products. They only use natural and organic ingredients, and their product even qualifies as food-safe: you could eat it if you wanted to! The CBD in this product is third-party tested, organic, and GMO-free. It also uses CO2 extraction to guarantee even more purity. 

Made with coconut oil, hemp seed oil, beeswax, and vitamin E, it’s a simple, hydrating product that doesn’t risk irritating your face. One of the things we like the best about this product is that it also contains lemon and vanilla essence. This gives it a fresh, pleasant scent that also helps to relax you. 

Though it isn’t the cheapest product on our list, we think that its quality completely justifies its $64 price tag. It contains such a high potency of CBD that you could use it for months before running out, and it’s made with the highest grade of ingredients you can find. 


  • Fast to absorb into the skin
  • Natural ingredients
  • High potency product


  • Some people might find its lemon and vanilla smell too strong to apply to the face
  • Shipping times to the U.S can be longer than average
CBD Fx Calming And Moisturizing Balm Stick

2.CBDfx Calming Balm

Our second pick is this richly scented CBD balm by CBDfx.


If you’re looking for a product to apply all over your body as part of your self-care ritual, we think it’s ideal. Formulated with lavender, chamomile, and tea tree essential oils, it has a deeply relaxing scent that is perfect to use right before bed. 

In this product’s simple ingredient list, you’ll find moisturizing jojoba, and avocado oil as well as shea butter. Though it is quite thick, this product is suitable to apply on both your face and body without risking any kind of irritation.

Compared to some of our other picks, this is a relatively high-potency product. A 2-oz jar contains 750 mg of CBD, meaning you don’t necessarily need to use a lot to feel effects. If you’re looking for a product you only have to apply to your temples and not your whole body, it’s a solid option. 

You can find the 2-oz jar for $39.99, which offers very good value for your money. Not to mention, it’s also made with the highest possible grade of CBD, and it’s organic, solvent-free, and third-party tested for greater purity.


  • Relaxing lavender and chamomile scent
  • All-natural ingredients
  • High potency of broad-spectrum CBD
  • Affordable


  • Hard to spread on large areas of skin because of dense texture
  • Not the most portable product
CBD Salve Stick

3. Joy Organics Premium CBD Salve Stick

Our first option for those who want to give CBD topical products a try is this portable CBD stick by Joy Organics.

It’s a relatively thick balm that comes in an easy 0.5-oz stick format that will fit perfectly in your purse or backpack. For those who like to keep CBD around and reapply it throughout the day, we think it’s one of the most practical formats we’ve seen so far.

This salve contains a total of 250 mg of CBD, making it quite a powerful product. That being said, it’s also sure to last you a long time thanks to its thick consistency. Made with natural jojoba and hemp seed oil as well as beeswax for texture, it’s a dense product that becomes light and creamy once warmed up between your fingers for a few seconds. It has the added advantage of being scent-free, which some people find necessary for products that they use on their face on a daily basis.

The CBD in this product is completely organic, GMO-free, third-party tested and U.S-grown. Joy Organics is a highly reputable brand with a great record for efficiency and customer service. With that in mind, it’s a product that we whole-heartedly recommend to those who are trying out CBD topical products for the first time. 


  • Fast absorbing
  • Broad-spectrum CBD extract
  • Convenient travel format


  • Low CBD potency
  • Not the best price per milligram of CBD
Elixinol Full-Spectrum Hemp Balm:

4. Elixinol Full-Spectrum Hemp Balm

This is a great product if you want something full-spectrum that offers good value for money.


One of our favorite creams is this Elixinol balm, which not only does good, but also smells delicious. Scented with natural essential oils of lemon peel, wintergreen, and blue mallee eucalyptus oil, it leaves an invigorating yet calming fragrance on your skin. This may sound trivial, but a smell that can put a smile on your face is not to be neglected when you suffer from depression.

This product uses an organic, GMO-free, and third-party tested full-spectrum extract. In the world of topical CBD products, it’s still relatively rare to find full-spectrum products. We think this is a shame, as research has shown that cannabinoids and terpenes other than CBD have a lot of positive effects on mental wellness. 

You can apply this thick cream to your temple or foreheads, or give yourself a shoulders massage with it. Thanks to its dense texture, it offers a slow release of CBD, meaning that you can apply it to the skin and experience countinuous effects for a few hours afterwards. 

In terms of potency, it’s a cream that comes in a small, 50mg version, or in larger tubs with 250mg or 500mg of CBD. The potency you go for really depends on your own needs, and on  what you plan to do with the product (will you use small amounts on your forehead, or larger amounts on your whole body?) The smallest size comes in at just $9.99, wile the 500mg version costs $44.99. In terms of price per milligrams of CBD, there’s no denyting this is one of the best products out there.  


  • Terpene-rich full-spectrum hemp extract
  • All-natural list of ingredients
  • Different potency options available
  • Dark glass container


  • Slightly longer than average shipping times
  • Not scent-free
CBD Medic Massage Therapy Pain Relief Oil

5. Charlotte’s Web Massage Therapy Pain Relief Oil:

This Charlotte’s Web body oil is perfect for those who enjoy a relaxing massage.


This massage therapy oil by Charlotte’s Web is our best pick if you’re looking for a product with a truly luxurious feel. The jojoba, argan, and coconut oil in this product give it a beautiful consistency. It’s a lot thinner than other products on our list, making it perfect for using on larger areas of skin. If you want something you can rub your whole body with after a shower, this is definitely the one we recommend.

In this massage oil, you’ll find 200mg of CBD (which is a medium concentration), pain-fighting menthol and camphor, and spicy essential oils of myrrh and frankincense. The CBD extract is broad-spectrum, meaning that it contains a wide range of cannabinoids and terpenes. Combined with the terpenes in essential oils, this makes the product a lot stronger, and better able to lift up your mood and relieve anxious feelings. 

Finally, you can’t go wrong with a Charlotte’s Web product. Charlotte’s Web is a brand that has pioneered the world of CBD products for years. Today, they make some of the highest quality CBD extract you can find, and use all natural, organic ingredients. So if you’re looking for a product that’s not just high-quality, but also fun to use, give this massage oil a try.


  • Broad-spectrum CBD extract
  • Great texture
  • Warm, inviting scent
  • Absorbs rapidly


  • Contains only 200mg of CBD
  • Spend minimum to get free shipping
Endoca Hemp Whipped

6. Endoca Whipped Body Butter 1500mg

Those looking to use CBD all over their body will be delighted with the consistency of this whipped body butter by Endoca.


Made with all-natural and organic shea butter, cocoa butter, and coconut oil, it’s a creamy-textured product that gives your skin deep hydration alongside its usual relaxing benefits.

The CBD in this product is organic and sustainable, GMO-free, and third-party tested. In general, we trust Endoca to come up with products that are as simple and pure as they come. No fancy ingredients, no artificial colors or fragrance. Just tried and true ingredients, a great texture, and some of the best-quality CBD you can find. 

You can find this body butter in two different potencies, a 300-mg version and a 1,500-mg one. For those trying out CBD for the first time, the lower potency is a great way to try out topical CBD without committing to a large purchase. On the other hand, we find that the 1,500-mg version gives you the best value for your money and much faster results. 


  • Creamy texture is a joy to apply
  • Natural list of ingredients
  • Hydrates your skin with cocoa and shea butter


  • Not for you if you dislike sweet, vanilla scents
  • Endoca don’t have discounts on a regular basis

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