Best CBD Cream For Endometriosis

Living with endometriosis makes life difficult for hundreds of thousands of women. Although many people see it as “just a painful period, it’s actually a serious medical condition that can cause real harm. After being prescribed heavy painkillers or hormonal treatment, many women seek a more natural solution to their issue. And that’s where CBD comes into play. With powerful pain-killing properties, CBD can also help women with endometriosis relax, and prevent painful periods in the future.

But why is CBD cream so effective for endometriosis pain? What do you need to know about using it? And how do you choose a quality product that can provide real relief from endometriosis? Here is our buyer’s guide to the best CBD cream for women with endometriosis. 

What you need to know about using CBD cream for endometriosis and period cramps

CBD cream can be very effective for women with endometriosis because it relieves pain in targeted areas, and because it could regulate their endocannabinoid system, preventing painful periods in the future.

Endometriosis pain can sometimes be so powerful that it stops women with this condition from falling asleep, focusing at work, or even maintaining normal social interactions. For some women, it manifests in a sharp, biting pain. For others, it’s a dull sensation that drags on for days or weeks. 

Whatever the level of pain, CBD can help because it’s a natural painkiller. When we absorb it through the skin, it provides relief on the area where it’s applied, as well as to the muscle tissue and nerves located underneath. This means that massaging CBD cream for pain relief directly on the lower stomach or lower back could give you the relief you need during an endometriosis flare-up. 

As well as lowering pain, CBD can also relax the muscles that contract in the lower abdomen. When we experience a painful period or an endometriosis flare-up, the muscles of the abdomen contract with force. This causes a tension that makes the pain worse. This is also why women with endometriosis can benefit from holding a hot water bottle to their lower belly or taking a warm bath, because it relaxes the uterus muscles. Think of CBD cream for pain relief as something similar: it’s a product that helps your muscles relax, making your period more bearable. 

But that’s not all. We know that women with endometriosis experience pain because of a uterine lining that grows and sheds outside of the uterus. And as studies have shown, CBD could help address this root cause. In a 2010 study, scientists observed the effects of cannabinoids on mice with endometriosis. They found that when they activated endocannabinoid receptors, it reduced the growth of misplaced uterine lining. Although this is only an animal study, it does suggest that cannabinoids like CBD have the potential to address the root cause of endometriosis. 

By applying CBD cream to painful areas when you’re menstruating, or on a more regular basis, you can lower your pain levels in a natural way, and potentially prevent painful periods in the future! 


Choosing a good CBD Cream for Endometriosis

There are a few different ways to take CBD for endometriosis. CBD oil, gummies, or even a vape are all good options. However, using a CBD cream for pain can be particularly effective because it provides fast relief, is easy to dose, and targets exactly the area where you feel the most pain.

But not all CBD cream is created equal. This is why we’ve put together the guide below, which has a carefully curated selection of the best CBD cream for pain on the market.

Endoca Hemp Whipped

1. Endoca Whipped Body Butter 1,500 mg

Endoca’s 1,500 mg is our favorite CBD cream for endometriosis pain. It has a smooth consistency that is easy to apply to large areas of skin.

Some women with endometriosis report that it’s pleasant to massage into the lower belly or back for natural pain relief. 

Its non-toxic, natural ingredients include shea butter, coconut oil, cocoa butter, and vitamin E. They give it a smooth, rich texture that is perfect for giving yourself a massage. And they also make it into a highly moisturizing product, which could be ideal for applying to your body after taking a bath or a hot shower. 

Like all Endoca products, this whipped body butter is formulated with only natural, organic ingredients. Not only that, but it also follows best manufacturing practices and has certificates showing how pure the product is in terms of pesticides, heavy metals, and other toxins. 

The 1,500-mg tub gives you excellent value for money for a product of this quality. And since women with endometriosis know that they will experience painful periods regularly for the foreseeable future, it can certainly be a worthwhile investment.


  • Great texture makes it very easy to spread
  • All-natural ingredient list
  • High potency


  • Not for you if you’re not a fan of sweet vanilla scents
  • Not the most affordable product
Endoca Hemp Salve

2. Endoca Hemp Salve 750 mg

Our second choice for the best CBD cream for pain for women with endometriosis is this hemp-based salve.


Compared to body butter, this product has a thicker consistency and is more concentrated. 

Its thickness means that it takes longer for your body to absorb. On the one hand, it could mean that you don’t experience relief quite as fast. But on the other hand, it can be great because it means that you’ll experience more steady pain relief over the course of several hours, as your skin progressively absorbs the product.

The feel of the product is closer to that of an ointment, but it remains easy to apply once you warm it up in your hands. Formulated with hemp oil, coconut oil, and vitamin E, it’s a very natural product that also has great moisturizing potential.

One of the things we like about it is its fresh, lemony scent. It’s made with 100% organic lemon peel oil and vanilla extract, which give it a hint of scent and sweetness that is never overpowering.

At $64 for a tub, it offers good value for money because its thick consistency means that you’ll naturally useless, which could make it last for longer. 


  • High potency product
  • Natural, organic ingredients
  • Sustainable brand


  • The texture can make it a little hard to spread
  • More expensive than other products on our list

3.CBD Calming Balm by CBDfx

A great option for those who want to marry the calming effects of CBD with those of essential oils is this richly-scented balm by CBDfx.

Formulated with lavender, German chamomile, and tea tree essential oils, this ointment has a soothing scent which makes it very pleasant to apply all over your lower belly or back.

It also contains sunflower oil, rosehip oil, shea butter, and coconut oil, which give it a creamy texture and great moisturizing properties. And one of the things we like best about it is that it’s also enriched with calendula oil. In natural medicine, calendula oil is used to fight pain and is even said to improve your hormonal balance. Hemp works great in combination with other herbs and natural ingredients, we find that CBDfx do a very good job of using this to their advantage.

This balm has a moderate to high CBD potency. It contains 750mg of CBD in a 2 oz jar, which is a considerable amount. The CBD itself is top quality, it is third-party certified, organic, GMO-free, and is even GMP compliant, meaning that it follows very strict rules of manufacturing. The jar comes in at $39.99, offering you great value for money. Overall, it’s a great product for those who want something more than just CBD to soothe their endometriosis pain.


  • High potency
  • Great value for money
  • Broad-spectrum CBD
  • Regularly on offer


  • Slightly hard texture which could make it hard to spread
  • Not unscented
Joy Skin & Body Premium CB Salve

4. Premium CBD Salve 500mg by Joy Organics

This lavender and eucalyptus-scented salve by Joy Organics comes in a large bottle that has the optimal concentration of CBD for moderate to severe pain.


You can get it in a 1oz version, or in a larger, 2oz version which contains 1000mg of CBD. If CBD cream is something you’re using or planning on using on a regular basis, this could be a good investment.

Made with all-natural products, this cream has one of the most simple ingredient lists that we’ve seen: MCT oil, beeswax, CBD extract, lavender essential oil and eucalyptus essential oil. In essence, it’s a product that goes straight to the point, delivering the virtues of CBD in a richly hydrating formula.

Lavender and eucalyptus give it a pleasant, fresh scent. They’ve also been chosen to go into the products because they are known to relieve muscle pain. So when your uterus is acting up, massaging this product on your lower belly could give you exactly the relief you need.

With organic, third-party tested, and U.S-grown labels, it offers high-quality CBD for an affordable price. Get the smaller version for $54.95, or the double size for just $79.96. 


  • 100% natural ingredients
  • Comes in different potency options
  • THC-free


  • Strong smell of eucalyptus and lavender
  • Not the easiest to spread
Elixinol Full-Spectrum Hemp Balm:

5. Elixinol Full-Spectrum Hemp Balm

Women with endometriosis will enjoy this rich, fresh-smelling hemp balm that is made with full-spectrum CBD extract.


 It contains a wide range of soothing and moisturizing oils and butters like grapeseed oil, ucuuba butter, and andiroba oil. Its mix of essential oils is equally exotic, including nerolidol, copaiba oil, and Blue Mallee eucalyptus essential oil. 

Overall, this is a creamy product that smells delicious and can give you real pain relief. Being a full-spectrum product means that it contains all of the cannabinoids found in the cannabis plant, including THC. This is great news for endometriosis sufferers, as studies have shown that CBD and THC taken together offer great relief from period cramps and back pain.

Easy to apply, this is a creamy product that’s easy to massage into your lower back or belly. And the great thing is, it’ll leave your skin feeling moisturized and smelling fresh too!

In terms of value for money, we think it’s one of the most interesting products on this list. It costs $9.99 for the small version, and only up to $44.99 for the strong, 500mg version. Considering that it’s made with all-natural, organic ingredients, and CO2 extracted, third-party tested CBD, it’s certainly a good option for all types of budgets.


  • Very moisturizing
  • Fresh, natural scent
  • Has different potency options
  • Full-spectrum CBD extract


  • Longer than average shipping time
CBD Medic Massage Therapy Pain Relief Oil

6. Charlotte’s Web Massage Therapy Pain Relief Oil

This Charlotte’s Web massage oil is a great option for those who want to add CBD to their endometriosis self-care regimen.


One of our favorite products for people who suffer from endometriosis is this richly-scented massage oil by Charlotte’s Web. It has all the qualities of a high-grade massage oil: it’s hydrating, smells great, spreads easily, and absorbs fast. It also has the qualities of a  specialized CBD product for pain: it contains good amounts of CBD, as well as other pain-fighting botanicals like menthol and camphor. 

In this oil’s ingredient list, you’ll find moisturizing ingredients like argan oil, coconut oil, and jojoba oil. They give the oil a rich consistency and give it gentle hydrating properties. You’ll also find menthol and camphor, two ingredients which can relieve pain naturally and almost immediately. As soon as you apply the oil on your lower belly or back, you’ll feel the cooling, numbing effects of camphor and menthol. Then, as the CBD absorbs into your skin, you’ll start to feel even more thorough and longer-lasting pain relief. Formulated with 200mg of CBD in a 100mL bottle, it isn’t the strongest product out there. But considering you’ll tend to use more because of its consistency, it’s definitely strong enough to relieve most people’s cramps. 

One of the things which we enjoy the most about this product is its smell. It contains essential oils of frankincense and myrrh which give it a very natural, earthy and slightly spicy scent. There’s something about it that we find very relaxing, and we’re sure you’ll enjoy it as well if you’re someone who enjoys a bit of aromatherapy.

THC-free, GMO-free, and third-party certified, it’s a high-quality product that has everything we look for in a CBD topical. It’s a unique way to get pain relief while on your period and without a doubt one of the most luxurious ones. 


  • Broad-spectrum CBD
  • Pleasant warm scent
  • Very easy to apply
  • Absorbs easily and doesn’t leave a residue


  • Relatively low CBD potency
  • No free shipping below a certain spend


2010 study on the antiproliferative effects of cannabinoids on endometriosis cells

2018 review of research on cannabinoids and pain

2012 study on the effects of CBD for pain management (inflammatory and neuropathic)

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