Best CBD Cream for Restless Leg Syndrome (RLS)

To have restless leg syndrome (RLS) is to have an overpowering need to move your legs. It can also been known as Willis-Ekbom disease. Now, this condition has been considered a sleep disorder because it usually happens when the individual is trying to rest.

As you can imagine, this can have a HUGE impact on the life of a sufferer. There is no cure, but the good news is that there are some treatments that work to treat the condition. Leg massages, hot baths, and heating pads are all ways to control RLS. But there is one more…

The latest research has now meant thousands of RLS sufferers to start using CBD. Known as cannabidiol, this hemp compound can be taken in cream, oil, and even gummies!  With that said, the most popular way for RLS sufferers to use CBD is through creams.   

Whether for RLS or general anti-inflammation benefits, this guide is designed to reveal the best CBD creams for restless leg syndrome. We have worked hard to find only the top brands in the industry that use high-quality cannabidiol derived from hemp. Without further ado, let’s view the best CBD cream for RLS.


1. Endoca Whipped Body Butter 1500mg

This is our best CBD cream for restless leg syndrome that can be spread over the whole leg easily.


From the same brand as the salve above, the Whipped Butter is the best topical CBD for restless leg syndrome that covers the whole leg. Upon opening the rub we noticed how this cream was a lot smoother than the Hemp Salve. In fact, the butter-like consistency is a nice balance between runny and thick.

It’s perfect for spreading on large areas of inflammation, which makes it the popular choice for achy knees and injuries. I know of many people that use this cream over their whole body after showering. Personally, I use this over my lower back when it gets sore (I have a herniated disc).

The cream is made by combining cannabidiol with a mix of natural butters and oils, which makes it ideal for reducing inflammation and promoting soft skin.  It has the following ingredients: Shea Butter, Coconut Oil, Palm Oil, Cocoa Seed Butter, Beeswax, Root Starch Vanilla, and Beeswax Vitamin E.

You have the option between the 300mg CBD or 1500mg tub sizes. Personally, the 1500mg offers the best value for money, which takes care of my back pain for at least a month.


  • Very hydrating and leaves your skin feeling soft
  • Creamy, whipped texture
  • Natural ingredients
  • Dark glass container


  • Some people dislike its sweet vanilla scent
  • Endoca rarely offers discounts or promotions
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2. CBDfx Muscle Balm

One of our favorite pics for CBD cream that can soothe people with restless leg syndrome is this calming balm by CBDfx.


Formulated with gentle, natural ingredients like sunflower oil, grapeseed oil, and shea butter, it has good moisturizing properties and is easy to apply to your legs.

The main reason why we recommend this product is its scent. The mix of chamomile, lavender, and tea tree essential oils make for a deeply calming product that’s perfect to apply directly before sleep. As with any topical CBD product, you’ll want to make sure to take some minutes to massage it in to help the cannabidiol molecules absorb better. And because of this product’s rich, soothing scent, these few minutes of massaging can be just what you need to fall asleep peacefully.

The product comes in a relatively large, 2oz jar that contains 750mg of CBD. This is a high concentration that can give you the relief you need. And considering it will last you a while, we think it’s a worthy investment for only $39.99.


  • All-natural ingredients
  • Contains soothing evening primrose oil
  • Very hydrating thanks to shea butter
  • Relaxing scent


  • Texture is on the thick side
  • Not very portable (bulky tin)

3. Joy Organics Premium CBD Salve 500mg

This medium-dosed, fresh-smelling lavender and eucalyptus salve by Joy Organics is a great option for restless leg syndrome.

 It comes in a 1oz jar that contains 500mg of CBD, or a perfect concentration for moderate pain and discomfort.

Its ingredient list is remarkably simple, with only organic MCT oil, beeswax, CBD extract, lavender, and eucalyptus essential oils. In other words, you know exactly what you’re putting on your skin! The MCT oil is deeply hydrating, while the beeswax gives this CBD cream a balm-like thickness that makes it easier to keep for longer.

The lavender and eucalyptus essential oils add a lot in terms of scent, but also in terms of benefits. As you may know already, essential oils contain terpenes, plant compounds that have beneficial properties. Terpenes are also known to reinforce the benefits of cannabinoids like CBD. So by mixing together CBD and essential oils, you can expect to get more of the benefits of this compound. Not to mention, lavender and eucalyptus have soothing and relaxing properties that make this product a joy to use.

At $54.95 for a 1oz jar, this product is a worthy investment that can last you a while. Our personal recommendation would be to apply it just before bed, the lavender is sure to facilitate a restful sleep! 


  • High-quality CBD extract
  • 100% THC-free
  • Dark glass container
  • Organic brand


  • Only ships to the U.S
  • Thick texture that can be hard to spread
Hemp Balm

4. Elixinol Full-Spectrum Hemp Balm

This unique balm contains full-spectrum CBD extract and rare ingredients like ucuuba butter, andiroba oil, copaiba oil, and Blue Mallee eucalyptus essential oil.


It’s a great option for people with restless leg syndrome, as it contains soothing ingredients that can relax you in preparation for sleep. In addition, lemon peel, eucalyptus, nerolidol, and calendula grant this product a fresh, natural smell that invites instant relaxation.

In the ingredients, copaiba essential oil has natural painkilling properties, as do rosemary leaf extract and calendula flower extract. All of the ingredients in this product are completely natural, and organic. The CBD extract itself is full-spectrum, meaning that it contains the widest possible range of cannabinoids and terpenes. Since many of these molecules work better together, you can expect even better results from a full-spectrum product (though be aware that it shouldn’t be used on children and pets.) 

As with all Elixinol products, this balm is third-party tested for quality and made with organic, GMO-free ingredients. It comes in an opaque container that preserves freshness, and you can even get it in 3 different sizes. For just $9.99, the smallest available size can be a great way to give CBD a try for the first time, while the larger 250 and 500mg version offer great value for money and stronger potency. 


  • Full-spectrum CBD extract
  • Natural ingredients
  • A lot of soothing ingredients
  • A few different potency options


  • Some potency options can be too light to relieve spasms
  • Slightly longer than average shipping times

5. Charlotte’s Web Massage Therapy Pain Relief Oil:

This massage oil is a great option for those who want a product that smells great and spreads easily.


Rubbing CBD into your legs is made incredibly easy by this fluid, richly-scented massage oil. U.S. brand Charlotte’s Web have created a product that not only smells great, but also absorbs easily and delivers CBD in a rapid way. 

Compared to a lot of other products on this list, this topical is a lot easier to apply. It comes in the form of a massage oil, which you can use by putting some drops in the palm of your hands and massaging it into your leg. It contains natural, hydrating ingredients like jojoba oil, coconut oil, and argan oil. And it’s also enriched with menthol and camphor, both of which boost its pain-relieving properties.

One of the things which we really enjoy about this product is its smell. It contains myrrh and frankincence essential oils which give it a very gentle scent, party spicy, part earthy, part sweet. It’s relatively subtle and doesn’t linger on your skin, but it’s also very relaxing and makes the product a joy to use. 

If you’re looking for a high-quality product that contains a medium dose of CBD (200mg per bottle) and that’s easy to spread on the skin, this one is our top recommendation.


  • Thin texture makes it very easy to apply to the whole leg
  • Broad-spectrum CBD extract
  • Absorbs rapidly
  • Pleasant scent


  • Low CBD potency
  • No free shipping below a minimum spenD

6. Endoca Hemp Salve 750mg

This thick CBD topical is our best CBD salve for restless leg syndrome.


Without doubt, the Endoca Hemp Salve is our favourite cream from all the CBD creams that we have tested. It is a concentrated and thick consistency, which makes it ideal for concentrated areas.

As soon as we opened the tub we were immediately treated to a delightful smell of fresh lemon. We then noticed the firm consistency of the product, which meant we had to dig into the product to get a good amount onto our fingers. We knew this would be the best cream for RLS and especially inflammation lare-ups.

The nourishing CBD salve doesn’t just contain CBD. In fact, it contains a range of natural ingredients to promote smoothness: CBD (cannabidiol), Coconut Oil, Beeswax, Cannabis Sativa Seed Oil, Citrus Medica Limonum (Lemon) Peel Oil, Citral, Vanilla, Vitamin E.

Endoca ships worldwide, so anyone can purchase this CBD RLS cream. It is currently priced at $64 (or equivalent), which may seem on the high side, but this is very competitively priced when it comes to CBD creams. At the end of the day, it will come down to your individual budget. Click the button below to read product reviews.


  • Natural, food-safe ingredients
  • Fast shipping
  • Absorbs fast and doesn’t leave a residue


  • Dense texture that can be hard to spread
  • Longer shipping times outside of Europe

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